At a glance:
A new study in mice explains how even a single faulty copy of the BRCA1 gene can fuel tumor growth.
The findings suggest the dominant “two-hit” hypothesis of cancer development may not tell the full story behind how cancer arises.
Study identifies cellular changes that prime cancer-related genes for action and render cells vulnerable to tumor growth.
The findings can inform new treatments that block the priming effect to prevent breast cancer formation.
