Obese mice whose fat cells were genetically altered to produce an increased amount of the glucose-dependent insulinotropic polypeptide receptor (GIPR) lost more than a third of their body weight through a mechanism that burns energy, UT Southwestern Medical Center researchers report in a new study. Published in Cell Metabolism, the findings highlight the potential of GIPR – a protein thought of as a minor player in a class of popular weight-loss drugs – to have its own starring role in therapies to fight obesity.
