Detecting diseases early requires the rapid, continuous and convenient monitoring of vital biomarkers. Researchers from the National University of Singapore and the Agency for Science, Technology and Research have developed a novel sensor that enables the continuous, and real-time detection of solid-state epidermal biomarkers, a new category of health indicators. The team’s wearable, stretchable, hydrogel-based sensor overcomes the limitations of current methods that rely on biofluid samples, such as blood, urine and sweat. This makes it a promising alternative for wearable, continuous, and real-time health monitoring, facilitating the early detection of conditions such as cardiovascular diseases and stroke.