Cutting-edge fluorescent cholesterol probes now enable scientists to visualize cholesterol movement and distribution in live cells with unprecedented detail. By combining computer simulations with live-cell imaging, researchers have uncovered how different probe designs influence cholesterol probe behavior. These probes could reveal how cholesterol imbalances drive Alzheimer’s and other neurodegenerative disorders, aiding drug development to modulate lipid activity and potentially offering new treatments or prevention strategies.
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