A new study has unveiled a promising new treatment for frostbite, utilizing human-induced pluripotent stem cell (hiPSC)-derived skin organoids. These organoids, when combined with gelatin-hydrogel, have been shown to significantly accelerate wound healing, reduce inflammation, and promote the regeneration of epidermal stem cells in frostbite model mice. In the later stage of wound healing, the organoids regulate essential pathways to reduce fibroblast-to-myofibroblast transition and remodel the extracellular matrix (ECM), preventing abnormal scar formation. This innovative approach offers a fresh therapeutic strategy for frostbite, addressing the persistent challenges of delayed healing and scarring associated with severe frostbite injuries.
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